Fertility breakthroughs are evolving fast, especially for women over 40. From using your own blood in Platelet-Rich Plasma (PRP) to the newest advances with stem cells, exosomes, and intrauterine PRP, the possibilities for supporting ovarian and uterine health are expanding. Imagine giving your ovaries a “wake-up call,” improving egg quality, or creating a more receptive uterine lining—all with regenerative techniques designed to optimize fertility. While the research is still emerging, these approaches are sparking hope for women looking to expand their options and improve IVF outcomes.
Here’s a closer look at the most exciting techniques being explored right now:
Traditional Ovarian PRP
This is the foundational approach. PRP is prepared from a patient’s own blood and carefully injected into the ovaries under ultrasound guidance. The growth factors in PRP are thought to promote cellular repair and improve ovarian function, potentially enhancing egg quality and responsiveness.
PRP + Stem Cells
Some advanced clinics are taking things a step further by combining PRP with a patient’s own Mesenchymal Stem Cells (MSCs), typically harvested from a small sample of body fat via a mini-liposuction procedure. The idea is that stem cells provide a more comprehensive regenerative signal to the ovarian tissue, working alongside PRP to support ovarian rejuvenation.
Exosome Therapy
The newest frontier in regenerative fertility, exosome therapy involves introducing tiny, powerful messengers (usually derived from stem cells) that can deliver precise instructions for cellular repair and regeneration. Unlike PRP, which mainly provides growth factors, exosomes are thought to help the cells actively “know” how to repair themselves.
A Different Application: Intrauterine PRP (or “PRP Wash”)
PRP isn’t only being used for the ovaries. Intrauterine PRP involves gently infusing or “washing” PRP into the uterus to improve the lining’s thickness, blood flow, and overall receptivity. This can be particularly beneficial for embryo implantation, creating a more favorable environment for pregnancy.
What Women Are Reporting
Although research is still in its early stages and outcomes vary, some women are noticing promising results, such as:
- Significant drops in FSH levels, moving from high to optimal ranges
- Improved ovarian response during IVF cycles
- Higher-quality embryos compared to previous cycles
It’s important to remember that PRP and other regenerative fertility techniques are not magic fixes. They work best when combined with a strong foundation: optimal hormone balance, nutrient support, inflammation management, and overall reproductive health. Addressing these basics first dramatically improves the potential effectiveness of advanced interventions like PRP.
If you’re curious about PRP or regenerative fertility, the key is starting with a comprehensive understanding of your own fertility health. That’s exactly what I cover in my Fertile After 40 Masterclass, where I guide women through the science-backed steps to optimize fertility naturally, even before exploring advanced treatments.
Click here to join the masterclass and build the strong foundation your fertility journey deserves.